the obvious reason: their big-spending pharmaceutical advertisers would drop them like hot potatoes.. september 2007 (27).. therapy, hdl particle size got smaller (not a good thing) and the hdl worked less effectively to remove cholesterol from the body," mehta said..: "evidence for decreased calcitonin gene-related peptide (cgrp) receptors and compromised responsiveness to cgrp of fetoplacental vessels in preeclamptic pregnancies."